All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...

"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug ...

Other NSAIDs do not have this effect. Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx ...

Dodge & Cox’s January 2025 personnel update suggests that by year’s end, a generational leadership change that began to take shape at least six years ago will be complete. Careful planning has ...

The risk for recurrent cardiovascular events is high among patients with r-axSpA and a history of these events, though TNF inhibitor therapy may offer protective benefits.

Use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially over-the-counter formulations, and certain other drug classes are among the risk factors for community-acquired acute kidney injury (CA ...

3 Diclofenac is thought to exert its action by reducing prostaglandin synthesis through inhibition of the cyclo-oxygenase enzymes (COX-1 and COX-2). It is classified as a non-selective COX inhibitor, ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Some prescription NSAIDs have brand names, others are available only as generic medications. Several may be given by injection. Examples of both include: COX-2 selective inhibitors are a type of NSAID ...

COX-2 levels increase during developmental synaptic remodeling 5 and upregulation of synaptic activity 6. Moreover, COX-2 is involved in the coupling of synaptic plasticity with cerebral blood flow 7.