Selective inhibitors of COX-2-selective NSAIDs are effective antiinflammatory and analgesic drugs with improved upper-GI safety compared ... ischemic stroke, and transient ischemic attacks).

Vioxx was removed from the market in 2004 for its risk for stroke and heart attack. Another COX-2 inhibitor ... Celebrex had a lower risk of causing GI bleeding, GI ulcers, swelling, and high ...