Selective inhibitors of COX-2-selective NSAIDs are effective antiinflammatory and analgesic drugs with improved upper-GI safety compared ... ischemic stroke, and transient ischemic attacks).

Table 1. Suggested strategies for analgesic/anti-inflammatory treatment and cardiovascular prevention among patients with inflammatory disease and different levels of risk of vascular events.

Vioxx was removed from the market in 2004 for its risk for stroke and heart attack. Another COX-2 inhibitor ... Celebrex had a lower risk of causing GI bleeding, GI ulcers, swelling, and high ...

The mechanism of action of the ibuprofen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Famotidine is a competitive inhibitor ...