While pericytes are important regulators of capillary function and homeostasis, the lack of specific markers has hampered the ...

癌症背后的分子机制一直是科学研究的热点。在癌症的众多驱动因素中，TP53基因被誉为“基因组的守护者”，是人类体内最重要的肿瘤抑制基因之一。然而，这位“守护者”也常常成为癌症发展的“叛徒”，数据显示，大约50%的癌症患者都携带TP53基因的突变。这些突 ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

CRISPR/Cas9 has been widely applied to various plant species accelerating the pace of plant genome editing and precision breeding in crops. Unintended effects beyond off-target nucleotide mutations ...

51% of the business is held by the top 14 shareholders Ownership research along with analyst forecasts data help provide a good understanding of opportunities in a stock Every investor in CRISPR ...

The legacy of our ancient human relatives, "brain-eating-amoeba" infections, emerging viral threats, the promise and peril of genome editing, and much, much more — in 2024, Live Science covered ...

此外，团队成员也在其他V型CRISPR-Cas系统成员，如Cas12b、Cas12i和Cas12j，以及II型CRISPR-Cas9中观察到了这一现象。与Cas12a稍不同，Cas9仅在单链靶标DNA存在的情况下才会启动对pre-crRNA的spacer区的反式切割，且Cas9的HNH和RuvC结构域对于pre-crRNA的反式切割都是必需的。

Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou Zhejiang 310058, China ...

One of bacterial cells' most well-known defenses against these viruses is the CRISPR system ... a guide RNA that directs an enzyme called Cas9 to snip the viral DNA, preventing infection.

CRISPR-Cas9技术因其高效的基因编辑能力成为 ... 在这一技术中，研究人员利用Cre重组酶（CreERT2）将每个sgRNA分为活跃（Active）和非活跃（Inactive）两种 ...

Regulators just gave a gift to one of CRISPR Therapeutics' programs. The program can now progress through the development process faster. Still, it doesn't guarantee that the program will be a ...

The strength of this work is convincing, as it employed CRISPR/Cas9-mediated gene editing to generate two dual recombination systems, and mapped gNFATc1+ and PDGFR-α+ cells residing in dental and ...