Results We defined three patient clusters by mutational signatures independent of histomorphology. Cluster 1 (C1) was defined by spontaneous deamination of DNA 5-methylcytosine and defective mismatch ...

Moreover, the authenticity of the identified putative ARDs could not be confirmed through cytosine deamination (typical characteristic of ancient DNA fragment) at the ends of the reads corresponding ...

The COP is the supreme decision-making body of the Convention. All States that are Parties to the Convention are represented at the COP, at which they review the implementation of the Convention and ...

Monkeypox, a zoonotic virus in the Orthopoxvirus genus, has drawn global attention for its impact on public health. In the current Mpox outbreak, a novel clade, Ib, has emerged as a significant and ...

A diary entry of a North Korean soldier deployed to fight in the Russia-Ukraine war has revealed how Pyongang's troops are being used as "drone bait", as "cannon fodder" in the brutal war. Wall ...

DNMT inhibitors, such as azacitidine and decitabine, exert their effects by targeting DNMTs which are responsible for adding methyl groups to cytosine residues in DNA leading to altered gene ...

The foot is a complex structure made up of 28 bones, 33 joints, 19 muscles, over 100 tendons and ligaments, and more than 200,000 different nerve endings. These work together to allow you to walk, run ...