Results We defined three patient clusters by mutational signatures independent of histomorphology. Cluster 1 (C1) was defined by spontaneous deamination of DNA 5-methylcytosine and defective mismatch ...

The foot is a complex structure made up of 28 bones, 33 joints, 19 muscles, over 100 tendons and ligaments, and more than 200,000 different nerve endings. These work together to allow you to walk, run ...

Monkeypox, a zoonotic virus in the Orthopoxvirus genus, has drawn global attention for its impact on public health. In the current Mpox outbreak, a novel clade, Ib, has emerged as a significant and ...

Moreover, the authenticity of the identified putative ARDs could not be confirmed through cytosine deamination (typical characteristic of ancient DNA fragment) at the ends of the reads corresponding ...

DNMT inhibitors, such as azacitidine and decitabine, exert their effects by targeting DNMTs which are responsible for adding methyl groups to cytosine residues in DNA leading to altered gene ...

Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, California 90032, United States ...

Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of ...