Ibrilatazar is under clinical development by Ability Pharmaceuticals and currently in Phase III for Metastatic Pancreatic Cancer.

Altered target enzymes (increased dihydrofolate reductase activity or expression, kinetically altered dihydrofolate reductase, increased 5-aminoimidazole-4-carboxamide ribonucleotide ...

After absorption, folates are reduced to the active form (tetrahydrofolic acid) by dihydrofolate reductase, and this active form is stored mainly in the liver. The US has an aggressive policy of ...

Methotrexate sodium tablets are a dihydrofolate reductase inhibitor indicated for the: Treatment of adults with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance ...

Department of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, USA Stowers Institute for Medical Research, Kansas City, USA ...

Methotrexate sodium tablets are a dihydrofolate reductase inhibitor indicated for the: Treatment of adults with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance ...

In 2023, 10.8 million people fell ill with tuberculosis (TB) with an estimated 1.25 million deaths globally. While 400,000 people were diagnosed with multi-drug resistant (MDR) and/or ...

Introduction: Dengue Fever continues to pose a global threat due to the widespread distribution of its vector mosquitoes, Aedes aegypti and Aedes albopictus. While the WHO-approved vaccine, Dengvaxia, ...