2005; Liang, 2009; Vranová et al., 2012). In spite of their broad diversity of functions and structures, the biosynthesis of all isoprenoids in plants invariably requires two five-carbon (C5) building ...

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Translational Data Analytics Institute, The Ohio State University, Columbus, Ohio 43210, United States ...

With significant reductions in mortality and risk of progression to AIDS in the era of highly active antiretroviral therapy (HAART), complications of long-standing HIV infection and treatment have ...

4 TMAO was measured by high-performance liquid chromatography as previously described. 2 On the day of study inclusion, PR was measured on a Coulter FC500 flow cytometer (Coulter Krefeld, Germany) by ...

a FDA = Food and Drug Administration; CYP2C9 = cytochrome P-450 isoenzyme 2C9; VKORC1 = vitamin K epoxide reductase complex subunit 1; UGT1A1 = uridine diphosphate-glucuronosyltransferase 1A1 ...

As humans do not synthesize dTDP-l-rhamnose, the four enzymes of its metabolic pathway represent very appealing targets against which new drugs might be designed. Analysis of V. cholerae mutants ...

Purpose: The basic concepts of pharmacogenetics, pharmacogenetic study approaches, factors to consider when applying pharmacogenetic discoveries to patient care, and potential roles for ...

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From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

Consumption of a high fat diet (HFD) is linked to metabolic syndrome and cognitive impairments. This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Pro-inflammatory macrophage activation is a ...

Oxidative stress is an important driver of aging and has been linked to numerous neurodegenerative disorders, including Alzheimer’s disease. A key pathological hallmark of Alzheimer’s are filamentous ...