As humans do not synthesize dTDP-l-rhamnose, the four enzymes of its metabolic pathway represent very appealing targets against which new drugs might be designed. Analysis of V. cholerae mutants ...

In MTCH2-deleted NIH3T3L1 cells, AMP levels increase, similar to what is observed in HeLa cells, likely due to: (1) alterations in nucleotide metabolism (AMP, ADP, ATP), a common phenotype associated ...

4 TMAO was measured by high-performance liquid chromatography as previously described. 2 On the day of study inclusion, PR was measured on a Coulter FC500 flow cytometer (Coulter Krefeld, Germany) by ...

a FDA = Food and Drug Administration; CYP2C9 = cytochrome P-450 isoenzyme 2C9; VKORC1 = vitamin K epoxide reductase complex subunit 1; UGT1A1 = uridine diphosphate-glucuronosyltransferase 1A1 ...

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Translational Data Analytics Institute, The Ohio State University, Columbus, Ohio 43210, United States ...

1 Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), ‘Federico II’ University of Naples, Naples, Italy 2 CEINGE Biotecnologie Avanzate, Naples, Italy We analyze the fundamental ...

All genomes encode the enzymes involved in the non-mevalonate pathway ultimately leading to farnesyl diphosphate but only SD1 and 3 Acidobacteria and C. thermophilum encode all three enzymes required ...

Clopidogrel metabolism and mechanism of action. Clopidogrel is metabolized to its active metabolite by the cytochrome P450 (CYP) 3A enzyme family. The CYP3A gene family is located on chromosome ...