It is caused by haploinsufficiency of the Lis1 gene product, which seems to be required for proper functioning of cytoplasmic dynein during neuronal proliferation, migration and morphogenesis.

The dynein axonemal heavy chain 2 (DNAH2) gene showed associations with uterine fibroids, age at menarche, testosterone, and sex hormone-binding globulin. The estrogen receptor 1 (ESR1 ...

Particularly, we are interested in how the distinct motors myosin, dynein and kinesin coordinate to transfer the endosome smoothly from the actin to the microtubule network, ensuring precise ...

† Most-abundant zymogen granule proteins. ‡ Different isoforms present in zymogen granules. § Validated by morphological studies after identification by mass spectrometry. As the molecular ...

Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In ...

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neurons migrate in a saltatory manner by ...

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This important study presents work on the molecular mechanism driving asymmetric cell division and fate decisions during embryonic development of echinoids. The evidence supporting the claims of the ...

1 Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan 2 Department of Biochemistry, Mie University Graduate School of Medicine, Tsu, Japan Functional ...