The eukaryotic organelle, the “peroxisome”, is now established as a key player in vital cellular processes. Peroxisomes are involved in the biosynthesis of membrane phospholipids, fatty acid ...

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, USA Department of Microbiology, UMass Chan Medical School, , USA ...

Expert Rev Cardiovasc Ther. 2008;6(3):391-409. Phosphatidic acid phosphatase/phosphohydrolase (PAP) is an enzyme that catalyzes the conversion of phosphatidic acid to ...

et al., 2022). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), which inhibits fatty acid oxidation by suppressing CPT-1a. By inhibiting lipolysis with Etomoxir, it ...

zju.edu.cn, zyyyych{at}zju.edu.cn Objective Accumulation of free fatty acids (FFAs) in hepatocytes induces lipotoxicity, leading to non-alcoholic fatty liver disease (NAFLD). This study aimed to ...

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent oxygenases in histone ...

Many plant hormones are produced through a process called β-oxidation in peroxisomes, including the pathway that makes salicylic acid. While the PAL pathway also involves β-oxidation ...

Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which proceeds slowly and cannot be ...

Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which is slow and cannot be directly attributed to hypertension or other cardiovascular disorders. This often ...

We all have a small amount of fat in our livers. That’s normal. Fatty liver disease happens when too much fat has built up in this essential organ; it’s diagnosed when fat makes up 5% of your ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...