Activation of Sirt1 potentiated the profibrotic effects of TGF-β with increased Smad reporter activity, elevated transcription of TGF-β target genes and enhanced release of collagen. In contrast, ...

Conclusions PDE4 inhibition reduces inflammatory cell activity and the release of profibrotic cytokines from M2 macrophages, leading to decreased fibroblast activation and collagen release ... the ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

Keywords: endoglin, peritoneal fibrosis, angiogenesis, EMT, TGF-β/ALK/Smads Citation: Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J and Wang H (2024) Corrigendum: Endoglin aggravates peritoneal ...

Through tissue tension, stretching promotes fibroblast activity and macrophage polarization, further amplifying anti-inflammatory responses. Together, these interventions strengthen macrophage ...

Effect of C7-T1 Extensional Posterior Transpedicle Osteotomy on Mobility and Quality of Life in Patients with Ankylosing Spondylitis Complicated with Lumbar Kyphosis and Related Factors.

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哺乳动物中存在三种高度同源的TGF-β亚型，即TGF-β1、TGF-β2、TGF-β3。在TGF-β超家族中，TGF-β亚型的研究最为广泛。根据癌症基因组图谱（TCGA ...