A new study highlighting the importance of a large protein complex called the exocyst in cell growth, division and ...

Like many rare diseases, fibrolamellar hepatocellular carcinoma (FLC) mounts a ferocious attack against an unlucky few—in ...

Tectonic's lead asset, TX45, is a long-acting Fc-relaxin fusion protein to treat group 2 pulmonary hypertension. Read why I'm ...

1 Laboratory of Molecular Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan 2 Department of Microbiology and Immunology, Tohoku University ...

The phase 1 clinical trial is a multicenter, open-label, dose-escalation study to assess drug safety via intravitreal ...

Researchers have developed an innovative immunotoxin (a fusion protein called GrB-Fc-KS49) designed to target epithelial membrane protein-2 (EMP2), a biomarker overexpressed in more than 75% of breast ...

Abstract: Proteins play crucial roles in diverse biological functions. Accurately annotating their functions is essential for understanding cellular mechanisms and developing therapies for complex ...

It uses a ligand-dependent destabilization domain that is fused to a protein of interest. Addition of a membrane-permeant small molecule, Shield1, reversibly stabilizes the fusion protein in a ...

The recent findings of Waldo et al. 1 demonstrate that the fusion of the green fluorescent protein (GFP) to insoluble proteins dramatically reduces its folding ability in prokaryotic cells.

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Like many rare diseases, fibrolamellar hepatocellular carcinoma (FLC) mounts a ferocious attack against an unlucky few-in this case, children, adolescents, and young adults.

One of the receptors for BAFF and APRIL is the transmembrane activator and CAML interactor (TACI). Telitacicept, an approved recombinant fusion protein of TACI has shown great clinical benefits in ...