An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

热休克蛋白90（HSP90）分子伴侣系统的共伴侣蛋白细胞分裂周期37（CDC37）蛋白在HSP90分子伴侣系统中负责招募待折叠成熟的激酶，随后与HSP90蛋白互作，进而将招募的客户激酶递送给HSP90蛋白。CDC37同时结合HSP90和激酶，在肿瘤细胞中过表达，成为潜在的药物靶标。

New tools may help us understand how Aha1 complexes interact and complement other hetero-oligomeric complexes with Hsp90 co-chaperones including FKBP51 and CDC37 in driving cancers and/or ...

2024年12月11日，中国科学技术大学生命科学与医学部黄成栋教授团队在 Nature Communications 期刊发表了题为“The Dynamic Triage Interplay of Hsp90 with its Chaperone Cycle and Client Binding”的研究论文。该研究利用液体核磁共振（NMR）技术，首次在原子分辨率上解析了Hsp90在ATP循环 ...