An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
New tools may help us understand how Aha1 complexes interact and complement other hetero-oligomeric complexes with Hsp90 co-chaperones including FKBP51 and CDC37 in driving cancers and/or ...
2024年12月11日,中国科学技术大学生命科学与医学部黄成栋教授团队在 Nature Communications 期刊发表了题为“The Dynamic Triage Interplay of Hsp90 with its Chaperone Cycle and Client Binding”的研究论文。该研究利用液体核磁共振(NMR)技术,首次在原子分辨率上解析了Hsp90在ATP循环 ...