Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.

Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.

Researchers from Vera Salus Ricerca Srl and affiliated organizations have reported the discovery and preclinical characterization of novel sigma-1 receptor (S1R) antagonists as potential new analgesic ...

Opioid-induced hyperalgesia (OIH) and allodynia (OIA) are abnormal pain states that result from the class of painkillers called opioids. It's something called a "paradoxical response" in which the ...

IgG MoDE Degraders: BHV-1300 Phase 1 completing last remaining dose cohorts with the optimized subcutaneous formulation with expected completion in 1H 2025. BHV-1310 first-in-human study anticipated ...

If you have recently visited your doctor for pain management and were surprised when they did not prescribe opioids, you are ...

The presence of an initiating noxious event or a cause of immobilization. Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to the inciting event. Evidence at ...

and mechanical hyperalgesia (increased sensitivity to painful stimuli) induced by TNF (tumor necrosis factor, a signaling protein produced by defense cells that plays a crucial role in regulating ...

and mechanical hyperalgesia (increased sensitivity to painful stimuli) induced by TNF (tumor necrosis factor, a signaling protein produced by defense cells that plays a crucial role in regulating ...

The pharmacokinetics, safety, and tolerability of four topical lidocaine patches 5% continuously applied for 72 hours and changed every 12 or 24 hours were examined. In this randomized ...