Joseph Priestley (1733–1804). This simplistic division of the roles of COX-1 and COX-2 drove the search for 'selective' COX-2 inhibitors and further fuelled the ranking of NSAIDs in terms of ...

Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

"Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes, COX-1 and COX-2, which are used by the body to make signaling molecules called ...

They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox enzymes, NSAIDs stop your body from ...

I’ve heard taking ibuprofen regularly could have consequences for my health. Is that true? You should avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs — such as ibuprofen ...

COX-2 is involved in prostaglandin synthesis and expressed throughout the nervous system, where it participates in pain sensitivity and in synaptic plasticity. Microsomal prostaglandin E synthase ...

There are two forms of cyclooxygenase—COX-1 and COX-2. Most NSAIDs affect both forms. Two OTC oral NSAIDs can be taken for osteoarthritis: Ibuprofen (Motrin, Advil, and generic versions), which can be ...

A couple of months ago, I was dealing with a sore lower back from overdoing yard work, so I took two ibuprofen tablets before going to bed for several nights in a row. What I noticed is that I was ...

NSAIDs like acetaminophen and ibuprofen are widely used for antipyretic and analgesic purposes. They reach this effect due to COX inhibition, thereby impairing the ultimate transformation of ...