Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Recent data suggests a direct link between the surface estrogen receptor and the mitogen-activated protein (MAP) kinase signaling cascade. MAP kinases are a family of serine–threonine kinases ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

To address the evolution of a complex mammalian network from a simple invertebrate cascade, we propose below ... The primordial receptor tyrosine kinase (RTK) might have been formed through ...

Here, the ways in which enteric bacterial pathogens utilise and impact on the three major physiological functions of the intestinal epithelium are discussed: alterations in the structure and function ...

Discover recent research that sheds light on a promising therapeutic strategy for tackling prostate cancer by targeting the ...

This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...

This is the official codebase for Stable Cascade. We provide training & inference scripts, as well as a variety of different models you can use. Therefore, this kind of model is well suited for usages ...

Glaucoma, the second leading cause of blindness globally, affects millions and is projected to reach 111.8 million cases by ...

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Additionally, the Phase 1 clinical trial evaluating QTX3034, an oral G12D-preferring multi-KRAS inhibitor, as a monotherapy and in combination with cetuximab, continues to enroll patients, and data is ...