Yale researchers discovered a molecular mechanism underlying lissencephaly—a rare brain development disorder—and found that activating the mTOR pathway can prevent and reverse malformations in brain ...

New Haven, Conn. — Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual ...

Yale University researchers have identified a molecular mechanism driving the structural abnormalities leading to lissencephaly that have, until recently, been elusive. Further, this research ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Yale researchers discovered that an underactive mTOR pathway drives structural malformations in lissencephaly. Using patient-derived brain organoids, they showed that activating the mTOR pathway ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

New Haven, Conn. — Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

After turning 29 years old on Christmas Day, McCreary is just one birthday away from being among the oldest people in the U.S. diagnosed with lissencephaly, a spectrum of severe and rare brain ...

What Is the Significance of the Different Anteroposterior Patterns of Malformation Severity in Classic Lissencephaly? Spectrum of lissencephaly severity caused by LIS1 deletions or mutations.