A number of comparative studies have been performed with metoprolol, a β 1-selective "second-generation" β blocker, and carvedilol, a nonselective and vasodilatative "third-generation" β blocker.

Maack et al. [70] recently reported on switching between β blockers (metoprolol and carvedilol) in 68 patients treated with either agent for 1 year who had improved in terms of LVEF and NYHA class.

The classification of drugs have been around since 1964 after Sir James Black discovered how they can assist people with ...

Carvedilol is a generic drug that’s prescribed for high blood pressure and other heart conditions in adults. As with other drugs, carvedilol can cause side effects, such as low blood pressure ...

For instance, the most common beta-blocker prescribed at enrollment was bisoprolol (71.5%), whereas only 1-1.3% of patients were taking metoprolol or carvedilol. The trial design was also limited by ...

Professor Poole-Wilson, Professor Coats and Dr Flather at Imperial and the Royal Brompton Hospital designed and led pioneering randomised clinical trials which defined the use of these agents in heart ...

Beta blockers are frequently mentioned in the news, such as when Los Angeles Chargers Head Coach Jim Harbaugh disclosed his battle with heart disease in October. A significant number of Americans, ...

In addition to blocking the receptor sites for catecholamines, third-generation β-blockers with associated vasodilating properties, such as carvedilol and nebivolol, provide a broad spectrum of ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...