Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise. Human induced pluripotent stem cells reprogrammed from ...

Pluripotent stem cells can become any cell type within the body, while multipotent stem cells are more limited, specializing in certain lineages. For instance, neural stem cells differentiate into ...

The emergence of induced pluripotent stem cell (iPSC) technology has had a great impact on the field of medicine ever since the ground-breaking discovery in 2006 that overexpression of four specific ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Human pluripotent stem cells (hPSCs) exist in ...

Functional maturation: By using the cocktails of growth factors, small molecules, and extracellular matrix, cells exhibiting mature features can be generated from pluripotent and multipotent stem ...

The hypothesis that an adult cell can give rise to an SC with pluripotent activity seems to defeat the tenets of developmental biology. This process would require reprogramming of an ASC to an ...

Cover picture: Inspired by the Review by Jung-Soon Mo, Hyun Woo Park and Kun-Liang Guan. Illustrated by Sandra Krahl.

Extracellular vesicles (EVs) have been widely recognized as a heterogeneous group of membrane-coated submicrometer particles released by different types of cells, including stem cells (SCs). Due to ...

This manuscript offers valuable information on the combinatory effect of small molecules, CHIR99021 and A-485 (2C), during the reprogramming of mature cardiomyocytes into regenerative cardiac cells on ...