Heart failure is the terminal stage of various cardiovascular diseases, usually characterized by pathological myocardial ...

1 Inner Mongolia Key Laboratory of Disease-Related Biomarkers, The Second Affiliated Hospital, Baotou Medical College, Baotou, China 2 School of Basic Medicine, Baotou Medical College, Baotou, China ...

HCM is typically characterized by asymmetric myocardial hypertrophy, which is often associated with diastolic dysfunction, LV outflow tract obstruction and mitral regurgitation. Myocardial cell ...

Figure 2: a, Baseline pressure–volume loops from control and mutant mice. The fall of in vivo cardiac output in hearts of older mice supports earlier data obtained in excised ejecting hearts 7 ...

For children with severe hypertrophic cardiomyopathy caused by gain-of-function RAS/mitogen-activated protein kinase ( ...

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe ...

Persistent smoking from age 10 through 24 years is associated with increased odds of premature cardiac and structural injury.

Cardiac arrest is when the heart stops abruptly with little or no warning. It is often fatal. According to American Heart ...

Background In hypertrophic cardiomyopathy (HCM), most of the factors associated with the risk of sudden cardiac death (SCD) are also involved in the pathophysiology of exercise limitation. The present ...

Discover Trametinib as a promising treatment for severe hypertrophic cardiomyopathy in children with RASopathies.