Spinal muscular atrophy (SMA) is a genetic, progressive disease that affects the nervous system and muscles. The life expectancy for people with SMA depends on the type of their disease and symptom ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

Due to the progressive nature of spinal muscular atrophy (SMA) — a rare genetic disease — an early diagnosis is critical. People with SMA who receive a timely diagnosis can start treatment immediately ...

The activated HSCs undergo continuous stimulation and proliferation, transdifferentiating into myofibroblasts that secrete large quantities of α-SMA and type I collagen, thereby contributing to ECM ...

Single-cell RNA sequencing reveals a profound loss of myofibroblasts in two models of BPD and identifies gene expression signatures of increased TGFβ signaling, cell cycle arrest, and impaired ...

Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world ...

The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

Therefore, a galectin-3 small molecule glycomimetic antagonist is in Phase 2B trials. Galectin-3 may mediate pathogenesis in alveolar epithelial cells (AECs) and myofibroblasts by nucleating a ...

Correspondence to Dr Christian Beyer, Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany; ...

Correspondence to Professor Dr Thomas Gress, Division of Gastroenterology, Endocrinology, Infectiology and Metabolism, University Hospital Giessen and Marburg, Campus Marburg, Philipps University ...