Spinal muscular atrophy (SMA) is a genetic, progressive disease that affects the nervous system and muscles. The life expectancy for people with SMA depends on the type of their disease and symptom ...

Due to the progressive nature of spinal muscular atrophy (SMA) — a rare genetic disease — an early diagnosis is critical. People with SMA who receive a timely diagnosis can start treatment immediately ...

The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

The activated HSCs undergo continuous stimulation and proliferation, transdifferentiating into myofibroblasts that secrete large quantities of α-SMA and type I collagen, thereby contributing to ECM ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

This is a useful report of a spatially-extended model to study the complex interactions between immune cells, fibroblasts, and cancer cells, providing insights into how fibroblast activation can ...

Single-cell RNA sequencing reveals a profound loss of myofibroblasts in two models of BPD and identifies gene expression signatures of increased TGFβ signaling, cell cycle arrest, and impaired ...