Analyst recommends Novartis as a Buy for long-term investors, BioAge a Hold, following strategic partnership for age-related ...

In addition to its CNS focus, Jupiter is evaluating opportunities in longevity and metabolic health. Emerging data suggests that JOTROL’s inhibition of NLRP3, when combined with GLP-1 treatments, ...

Jupiter Neurosciences (JUNS) announced a strategic focus on targeting the NLRP3 inflammasome in all upcoming clinical trials. This shift aims ...

Entering 2025, Rezolve Ai boasts an improved balance sheet, a growing customer base, and an ambitious sales and marketing strategy targeting the United States and key European markets. These ...

In addition to its CNS focus, Jupiter is evaluating opportunities in longevity and metabolic health. Emerging data suggests that JOTROL’s inhibition of NLRP3, when combined with GLP-1 treatments, ...

吸烟对心血管健康的有害影响，特别是动脉粥样硬化和血栓形成，已经得到了很好的证实，更详细的机制也在不断出现。作为吸烟不良影响的基本病理生理学，内皮功能障碍、炎症和血栓形成被认为尤为重要。香烟烟雾诱导内皮功能障碍，导致血管扩张和止血调节受损。导致内皮功能障碍的因素包括一氧化氮生物利用度降低、超氧阴离子水平升高和内皮素释放。血管壁的慢性炎症是吸烟诱导动脉粥样硬化的核心发病机制。吸烟会全身性升高炎症标志物 ...

Objectives The objectives were to identify intracellular pathways induced by CPPD crystals and leading to NLRP3 activation and IL-1β production. Conclusions IL-1β production triggered by m- and t-CPPD ...

Results We observed that MSU and CPP crystals led to a metabolic rewiring toward the aerobic glycolysis pathway explained by an increase in GLUT1 plasma membrane ... and treatment with either ...

It is likely, however, that future studies will reveal a more extensive role of this pathway in inflammatory diseases. A greater understanding of the modulators of Wnt expression and the noncanonical ...

In recognising this UK Sport’s approach to funding reflects that journey and works on the basis of an athlete pathway with three clear and distinct levels that make up the World Class Pathway. The two ...

【导读】脑内出血（ICH）是严重类型的脑卒中，具有高死亡率和有限的选择治疗。12月23日，郑大一附院与中国科学院以及台北医学大学研究人员合作共同在期刊《Cell Death&Disease》上发表了研究论文，题为“Sphk1/S1P pathway ...