天冬氨酸如何帮助癌细胞建立这个“度假胜地”呢？答案出人意料。天冬氨酸并没有直接被癌细胞摄取，而是通过激活一种名为NMDA受体的细胞表面蛋白来触发一系列信号级联反应。这一过程最终导致了一种特殊的蛋白质起始因子eIF5A发生酪氨酸异构化（hypusina ...

在癌症的发展过程中，转移是导致患者预后不良的主要原因之一。统计数据显示，超过一半（54%）的癌症转移案例发生在肺部。这引发了科学家们的好奇：为什么肺部会成为癌细胞偏爱的目标？最近，《自然》杂志上发表的一项由鲁汶VIB-KU癌症生物学中心主导的研究揭示 ...

在癌症患者的转移过程中，肺部往往成为癌细胞转移的首选目标，令人困惑。根据最近发表于《自然》杂志的一项研究，科学家们发现这一现象与一种常见的氨基酸——天冬氨酸的浓度密切相关。研究指出，肺部癌症患者的肺部天冬氨酸水平显著高于健康小鼠和不患癌的人群。

研究者观察到，在 乳腺癌 肺转移患者的肺部中，天冬氨酸水平异常之高。天冬氨酸会激活癌细胞表面的NMDA受体，导致级联反应，最终完成了非经典翻译起始因子eIF5A的翻译后修饰。eIF5A的改变增加了TGF β ...

Magnesium supports heart health, bone strength, alleviates insomnia, and reduces stress, but consumption should be monitored.

Tyrosine phosphorylation can upregulate NMDA receptor activity during pathological and physiological alterations of synaptic strength. Here we describe downregulation of recombinant NR1/2A ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

This is when antibodies produced by the immune system attack the brain’s own proteins, in this case its NMDA receptors. This receptor is involved in learning and memory, therefore sufferers ...

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, ...