Scientists at the University of California, Irvine, have discovered that nuclear speckles, a membraneless organelle within ...

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Small GTPases of the RAS family classically function as molecular switches, adopting on and off conformations dependent on bound nucleotides. Here the authors reveal MRAS, closely related to ...

A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to ...