Mutation or dysregulation of tumour-suppressor ... The binding of a DARPin to p53 displaces the human papillomavirus (HPV) E6 protein and stabilizes p53 in HPV-infected cells.

Frontier Medicines Corp. has announced the selection of FMC-220, a first-in-class covalent small-molecule activator of p53 Y220C designed to address potency and tolerability challenges of noncovalent ...

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

Discover recent research that sheds light on a promising therapeutic strategy for tackling prostate cancer by targeting the ...

Genetic sequences of H5N1 bird flu viruses collected from a person in Louisiana who became severely ill show signs of development of several mutations thought to affect the virus’ ability to ...

The new drug application of glecirasib is currently under evaluation by the Center for Drug Evaluation of the National Medical Products Administration of China, and has been granted Priority Review ...

New research suggests a genetic mutation previously believed to promote esophageal cancer might actually play a protective ...

Scientists from the Barts Cancer Institute and the Francis Crick Institute have demonstrated that a genetic flaw that has ...

This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...

A surprising discovery reveals that a gene previously thought to accelerate esophageal cancer actually helps protect against it initially. This pivotal study could lead to better prediction and ...

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease. This unexpected discovery could help doctors identify which ...

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.