We demonstrate that activation of P2X7 deregulates LC3-II and p62 protein content. Moreover, in vivo treatment with the specific ... Receptor localization, native tissue binding and ex vivo occupancy ...

如图1C所示，抗p72标记的病毒粒子在2 hpi时与红色荧光LC3点部分共定位，但在感染后期，LC3和新合成的p72几乎没有共定位。 由于SQSTM1/ p62在自噬过程中起关键作用，对病毒感染具有反应性，并且易于检测，因此与LC3一样，被广泛用作研究自噬的标志性标记。

Autophagosomes form at points of contact between the endoplasmic reticulum (ER) and mitochondria, and two ubiquitin-like conjugation systems (Atg12 and Atg8/LC3) extend a double-membraned ...

1 Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

In our ageing population, neurodegenerative disorders carry an enormous personal, societal and economic burden. Although neurodegenerative diseases are often thought of as clinicopathological entities ...