These data suggest PI3 kinase/mTOR signalling is an important component in TGF-β 1 induced αSMA and collagen gene expression and that an mTOR dependent, Akt independent pathway mediates this ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Near the end of the last decade, Novartis had two similar drugs advancing through clinical development. Known as PI3 kinase inhibitors because of the enzyme they target, the drugs steadily moved ...

Despite these differences, the authors found that chemotaxis and electrotaxis share a dependence on similar intracellular signaling molecules, most notably the phosphoinositide 3-kinase (PI3K ...

In a report released today, Gregory Renza from RBC Capital reiterated a Buy rating on Verastem (VSTM – Research Report), with a price target of ...

Mizuho Securities analyst Graig Suvannavejh maintained a Buy rating on Verastem (VSTM – Research Report) today and set a price target of $9.00.

Linperlisib is under clinical development by Shanghai Yingli Pharmaceutical and currently in Phase I for Hematological Tumor.

The addition of Truqap to standard-of-care therapy improved radiographic progression-free survival in patients with ...

Johnson & Johnson, already a big player in neuroscience drugs, is adding to its portfolio and pipeline with a deal to acquire ...

产品活性： Alpelisib (BYL-719) 是有效，选择性的，具有口服活性的 PI3Kα 抑制剂。Alpelisib (BYL-719) 对 PIK3CA 突变癌具有靶向性。Alpelisib (BYL-719) 抑制 p110α、p110γ ...