The insulin receptor together with the serotonin transporter regulates the selective sucrose appetite. We provide evidence that the cellular location of the serotonin transporter depends on the ...

Tirzepatide, first approved for type 2 diabetes, exploded in 2023 when the FDA approved it for weight loss as Zepbound. The drug is a dual agonist of the GLP-1 and GIP receptors—key mediators of ...

Last month, a real-world study linked Novo’s semaglutide with a 40% to 70% drop in the risk of Alzheimer’s disease in patients with type 2 diabetes, versus treatment with insulin. A few months earlier ...

A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...