The insulin receptor together with the serotonin transporter regulates the selective sucrose appetite. We provide evidence that the cellular location of the serotonin transporter depends on the ...

Tirzepatide, first approved for type 2 diabetes, exploded in 2023 when the FDA approved it for weight loss as Zepbound. The drug is a dual agonist of the GLP-1 and GIP receptors—key mediators of ...

Last month, a real-world study linked Novo’s semaglutide with a 40% to 70% drop in the risk of Alzheimer’s disease in patients with type 2 diabetes, versus treatment with insulin. A few months earlier ...

A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

We are aware of reports regarding supply issues of insulin in the UK. Here’s the latest information on how your treatment may be impacted.

Scientific evidence suggests that by downregulating growth factor receptor-bound protein 2 (Grb2) expression, BP1001-A could help lower blood glucose level by affecting insulin signaling.

In a phase 3 clinical trial (NCT05438407) among children aged 4 to 11 years with activated phosphoinositide 3-kinase delta syndrome (APDS), leniolisib (Joenja; Pharming Group N.V.) demonstrated ...

Type 1 diabetes (T1D) is a chronic autoimmune disease that involves the autoimmune destruction of insulin-secreting pancreatic β-cells, resulting in disturbed glucose regulation and overt ...

Professor Chris Bakal’s group uses genomic approaches and computational modelling to understand how complex biochemical signalling networks are ‘rewired’ during the development of cancer. Our goal is ...

In the case of the crosstalk between pancreatic β-cells and the liver, only one factor has been found to date. This protein, pancreatic derived factor (PANDER) has been proposed as a novel linker ...