This is of particular concern since peripheral edema was one of the several criteria employed to reach the diagnosis of CHF. Peripheral edema is a not too uncommon finding with direct vasodilators ...
No loss in sensation at the application site was reported. No patient had edema, and most cases of erythema were very slight. No systemic adverse events were judged to be related to the patches.
hypothermia in the elderly in cold houses) or peripheral circulation problems such as trench foot and frostbite ... pulse may not be palpable 78º - 75ºF Pulmonary edema, cardiac and respiratory ...