The data demonstrate increased neurotransmitter release and alteration in synapse ultrastructure with higher number of docked vesicles and shorter AZ. The evaluation of presynaptic function of SNX4 is ...

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are ...

Exocytosis, the fusion of secretory vesicles with the plasma membrane to allow release of the contents of the vesicles into the extracellular environment, and endocytosis, the internalization of ...

To do this, the synaptic vesicle must dock at the membrane of the presynaptic neuron and dump its content into the synapse, where it moves to particular receptors on the postsynaptic neuron.

How an electrical signal crosses that synaptic gap is not yet entirely understood, but the basic process seems to go like this: a presynaptic neuron receives a message that it has information to ...

This month's cover highlights the article A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets by Stacey D. Gilk, Rajendra Angara and Arif Sadi. The ...

Many of the neuropeptide receptors expressed centrally are also expressed peripherally and thus actions of agonists or antagonists of these receptors cannot be assumed to induce weight loss by ...

1 Second Hospital, Shanxi Medical University, Taiyuan, China 2 Henan Academy of Innovations in Medical Science, Brain Institute, Zhengzhou, China Parkinson’s disease (PD) is a chronic, progressive ...

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