Small GTPases of the Rho family are potent modulators of the actin and microtubule cytoskeleton. Recent data indicate that the Ras-like RAP1 protein and various Rho proteins crosstalk to polarity ...

Ras proteins have been studied intensively ... more of a concern when analogous dominant-inhibitory versions of Rho-family GTPases, such as Rho, Rac and Cdc42, are used. Many of the nucleotide ...

Scientists at Boehringer Ingelheim Pharma GmbH & Co. KG and Vanderbilt University have described GTPase KRAS and/or its mutant inhibitors reported to be useful for the treatment of cancer.

with the exception of the notorious cancer-causing GTPase called K-Ras. On a hunch, the team tested a dozen drugs that target K-Ras against a handful of GTPases they had mutated to make them more ...