Receptor-interacting protein kinase 3 (RIPK3), a key signaling molecule, is known to play a critical role in necroptosis, making it a promising target for therapeutic intervention. To identify ...

研究成果以“细胞外RIPK3作为损伤相关分子模式加重心脏缺血/再灌损伤（Extracellular RIPK3 acts as a damage-associated molecular pattern to ...

In patients with transthyretin amyloid cardiomyopathy, the high-affinity TTR stabilizer, acoramidis, is associated with better clinical outcomes compared with placebo. Acoramidis is associated with ...

Even as Biogen and Eisai’s Leqembi and Eli Lilly’s Kisunla slowly roll out onto the market, experts question the efficacy of these anti-amyloid antibodies and the amyloid hypothesis overall. Despite ...

这项研究揭示了血浆中受体相互作用蛋白激酶3（RIPK3）在心肌缺血再灌注损伤中的重要作用，并发现其水平与主要不良心血管事件（MACE）的发生呈正相关。 研究涵盖了437例接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死患者，发现那些发生MACE的患者在PCI后6 ...

你有没有想过心肌梗死患者的命运，是如何在一次简单的介入治疗后发生改变的？近期，北京协和医院、北京大学第三医院和西安交大第一附属医院的研究团队在《Circulation》杂志发表了一项重要研究，揭示了一种名为受体相互作用蛋白激酶3（RIPK3）的新型分子 ...

Receptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are absent in specific vertebrate ...

Multiple myeloma and AL amyloidosis are conditions linked to plasma cells in the bone marrow. Multiple myeloma (MM) is a cancer affecting the plasma cells, which are mostly in the bone marrow.

The manuscript titled "Evolutionary and Functional Analyses Reveal a Role for the RHIM in Tuning RIPK3 Activity Across Vertebrates" by Fay et al. explores the function of RIPK gene family members ...