Signaling via phosphorylation-regulated protein-protein interactions often involves flexible or unstructured proteins. Detailed biophysical and computational studies on one such interaction reveal ...

Increased understanding of signal transduction mechanisms and gene regulation involved in immune responses has created opportunities for the discovery of novel therapeutic compounds useful in treating ...

Once a protein has its shape, it can bind to other selected molecules in order to carry out its function. That function could be signaling, storing, transporting, providing structure, fighting foreign ...

CXCL13, a signaling protein that is produced immediately after infection with B. burgdorferi and triggers an immune response, could provide a more accurate diagnosis—if it were known at what ...

This valuable study investigates how the proteins of the Cdv division system in Metallosphaera sedula archaea sequentially interact with curved membranes in vitro, extending our understanding of this ...

Researchers at the Francis Crick Institute and Barts Cancer Institute, Queen Mary University of London, have shown that the amount of a protein called CD74 can indicate which people with bowel cancer ...

Scientists have uncovered how developing neurons migrate from the germinal zone, a process critical for proper brain circuit ...

Ram Savan explained that some proteins in the body act as sentinels. When they detect the presence of RNA viruses, they activate interferons through the mitochondrial antiviral signaling (MAVS ...

6H). cGAS and RIG-I sense different ligands and signal via distinct adaptor proteins, but both their signaling cascades converge at the level of TBK1/IKK/IRF3/NF-κB p65, ultimately leading to the ...