The biology of RNA interference has greatly facilitated analysis of loss-of-function phenotypes, but correlating these phenotypes with small-molecule inhibition profiles is not always straightforward.

o Covalent inhibitors: Exploring the design and development of covalent inhibitors with enhanced target specificity. o Kinetic selectivity: Understanding structure-kinetic relationships of small ...

UICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United ...

“The start of the trial with our novel SOS1 small molecule inhibitor marks a significant step in our commitment to targeting key drivers of tumour cell survival and growth,” said Dominik Ruettinger, ...

Tasca’s most advanced drug candidate, CP-383, is a first-in-class molecule that has demonstrated robust anti-cancer activity in both in vitro and in vivo studies across a broad range of human cancers, ...

Further investigations showed that 2C robustly generates RCCs in adult mouse hearts and improves cardiac function in mice experiencing myocardial infarction. This proof-of-concept discovery ...

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Differential microRNA (miRNA) profiles have been implicated in the plasticity of TAMs ... Recently, poly-ADP ribose polymerase inhibitors (PARPi) have demonstrated efficacy in patients with deficient ...

Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) of the Ufa Federal Research Centre, Oktyabrya Prospekt 71, Ufa 450054, Russian Federation Moscow Institute of Physics and ...

Amy Danise is the managing editor for the insurance section at Forbes Advisor, which encompasses auto, home, renters, life, pet, travel, health and small business insurance. She is a highly ...