Although, preclinical data suggest that the behavioral expression of opioid use is similar between male and female rodents, we do not have conclusive results on sex differences on craving and relapse ...

In this Frontiers Research Topic, the authors review the current state of knowledge about dopamine receptor biology and signaling, how dopamine signals modulate synaptic plasticity and basic neural ...

and reduced synaptic vesicle exocytosis as assayed by membrane capacitance measurements, as well as greatly reduced in vivo spontaneous and sound-evoked spikes from the postsynaptic spiral ganglion ...

Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

Layer 5 pyramidal neurons, crucial for brain information processing, vary significantly in their synaptic protein composition based on neuron type.

In all of the experiments described below, glutamatergic and GABAergic synaptic transmission was blocked pharmacologically, and leak and capacitive currents were subtracted offline. Except where ...

Peptides have emerged as powerful tools in modern research, providing insight into diverse biological processes and potential ...

While bulk, single-cell and spatial transcriptomic analyses revealed an enriched transcriptional program related to synaptic transmission in the mouse tumors, their immunostaining and electron ...

While bulk, single-cell, and spatial transcriptomic analyses revealed an enriched transcriptional program related to synaptic transmission in the mouse tumors, their immunostaining and electron ...

While bulk, single-cell and spatial transcriptomic analyses revealed an enriched transcriptional program related to synaptic transmission in the mouse tumors, their immunostaining and electron ...

"It appears that cannabis disrupts the natural mechanism of synaptic strengthening and ... space between two neurons that facilitates the transmission of information from one to the other.