Tao et al. show that epidermal growth factor receptor and insulin-like growth factor 1 receptor activation enhances thymidine kinase 1 expression through ERK phosphorylation and deubiquitylation ...

Ubiquitylation is the post-translational modification process by which ubiquitin is attached via an isopeptide bond to lysine residues on a protein. Ubiquitylation consists of three steps ...

human chorionic gonadotropin, thymidine phosphorylase ... including tyrosine kinase inhibitors, mammalian target of rapamycin (mTOR) inhibitors (rapamycin), and the monoclonal antibody targeting ...

Buying Modis will add MT1621 to Zogenix’s pipeline, an investigational drug for thymidine kinase 2 deficiency (TK2d), an inherited mitochondrial DNA depletion disorder that affects children and ...

Presented updated clinical and biomarker activity data at the IOVC in October 2024. Investigators reported ongoing improved ...

Two anti-transferrin receptor (TfR) nanobodies, V H H123 specific for mouse TfR and V H H188 specific for human TfR (huTfR) were used to track transplants non-invasively by PET/CT in mouse models, ...

1 Department of Gastroenterology and Hepatology ... One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in ...

A creatine kinase test is a blood test that measures levels of an enzyme called creatine kinase. This enzyme supports energy production in the body and is particularly important for muscle and ...

This story was originally published on PharmaVoice. To receive daily news and insights, subscribe to our free daily PharmaVoice newsletter. This time last year, Candel Therapeutics was burning at ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cancer cells often display centrosome ...

for those've you who haven't seen the video they're reacting to, think: 2 girls, 1 cup… except it's a guy… and a (glass) jar… that goes up his ass… and shatters… and DESTROYS his anus… ENJOY!