as essential to the suppressive function of regulatory T cells (Tregs) in the tumor microenvironment (TME). This discovery ...

These TREG cells impede the function of the effectors in combating the tumor. The chemokine CCL22, produced by the tumor cells, binds to its receptor (CCR4) on the TREG cells and mediates their ...

Here the authors implicate heterochromatic gene silencing in the susceptibility of CD4 + T cell to regulatory T cell suppressive function in a murine allograft model of inflammation. Here ...

Three recent papers published in The Journal of Experimental Medicine show that microRNAs are needed to safeguard the function of regulatory T (T Reg) cells. So, although it is not clear which ...