The tension elevation activated the mechanosensitive ion channel Tmem63b and triggered Ca 2+ influx, leading to actomyosin activation at the rear of the cell. Blockade of this signaling pathway ...

More information: Jianmin Yin et al, Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1, Nature Communications (2024).

Three sets of conserved polarity proteins — the partitioning defective (PAR), Scribble and Crumbs complexes — regulate polarization processes in many different cell types and organisms ...

Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, Prof. Markus Affolter’s research team at the Biozentrum of the University ...

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team has uncovered new mechanisms in blood vessel formation.

Vascular system of a zebrafish embryo, with endothelial cells in green and blood cells in red. Credit: University of Basel Blood vessels are vital for our body, transporting essential nutrients and ...

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team at the Biozentrum of the University of Basel ...

In summary, extensive data support that titin’s passive force augments actomyosin interaction. At low passive force (short SLs), interactions between myosin heads and the A-band segment of titin may ...