Despite this, the pathogenesis of traumatically induced axonal injury remains unclear. Despite general agreement regarding the occurrence of secondary axotomy there has been little consensus with ...

The frequent poor functional outcomes after delayed surgical repair of injured human peripheral nerves results in progressive downregulation of growth-associated genes in parallel with reduced ...

1 Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic (ASCR), Prague, Czechia 2 Second Faculty of Medicine, Charles University, Prague ...

Here, the authors show that after axotomy, DLK kinase drives apoptotic mitochondrial fission in axons. Blocking this reduces axon degeneration and neuron death in both human and mouse models.

Neuropathic pain is a pervasive health concern worldwide, posing significant challenges to both clinicians and neuroscientists. While acute pain serves as a warning signal for potential tissue damage, ...

This important study leverages the power of Drosophila genetics and sparsely-labeled neurons to propose a new model for neuronal injury signaling. The authors present convincing evidence to support ...

During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...

Setting Malmö Diet Cancer Study (MDCS), Malmö, Sweden. Participants In a subcohort of 3898 individuals (recruited 1991–1996) from MDCS (baseline examination in 28 449 individuals; collection of ...