产品活性： PF-07104091 hydrate 是一种高效选择性的 CDK2/cyclin E1 和 GSK3β 抑制剂，其 Ki 分别为 1.16 和 537.81 nM。PF-07104091 hydrate ...

This MII arrest is mediated by XErp1/Emi2, which inhibits the ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome). Cyclin B3 in complex with Cdk1 (cyclin-dependent kinase 1) is essential to ...

FDA grants Fast Track Designation for azenosertib in Cyclin E1 positive cancer. Clinical data update to follow on January 29, 2025. Zentalis Pharmaceuticals announced that the U.S. FDA has granted ...

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial ...

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This month's cover highlights the article Local translatome sustains synaptic function in impaired Wallerian degeneration by Maria Paglione, Lukas Neukomm and colleagues. The image shows dissected ...

In a large-animal model study, researchers have found that heart attack recovery is aided by the injection of heart muscle ...

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil ...

Zentalis Pharmaceuticals has won a U.S. Food and Drug Administration fast-track designation for its lead product candidate azenosertib for certain cancer patients with high levels of the Cyclin E1 ...

Odyssey Therapeutics Inc. has synthesized CDK2/cyclin E1 inhibitors reported to be useful for the treatment of cancer.

CT表现 腹腔内靠近脊柱左前方腹膜后区域见不规则团片状稍低密度影，范围约 26 × 28 mm，边界尚清，病灶内部区域密度大致均匀，偏后方区域脂肪间隙模糊（冠状位蓝色箭头） 增强检查病灶动脉期明确不均匀性强化，内见小片状、裂隙状稍低密度影 ...