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4. The optimum temperature for chemical reactions to take place in the body is 98.6 degrees F. Above 105 F many body enzymes become denatured and chemical reactions cannot take place leading to death.

The vast majority of CICD reactions, however, are caused by one of seven basic irritant groups: calcium oxalate, protoanemonin, isothiocyanates, diterpene esters, bromelain, and alkaloids.