在一项新的研究中，来自丹娜法伯癌症研究院等多个研究机构的研究人员确定了罕见的生殖系结构变异是儿童非血液相关癌症的风险因素，包括各种器官的肿瘤。他们的研究结果表明，基因组编码区和非编码区的结构变异都会导致儿童癌症，如 神经母细胞瘤 、尤文氏肉瘤和 ...

Germline gene therapy and somatic gene therapy are two quite different proposals, and the legitimate concerns and risks of the former should not be used to stall progress on the latter.

Germline development is the development of the cell lineage that gives rise to the reproductive cells, called gametes, of sexually reproducing organisms. Primordial germ cells, the founder cells ...

Researchers at Dana-Farber Cancer Institute collaborated with multiple institutions to pinpoint rare germline structural ...

Largescale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, such as Ewing sarcoma, neuroblastoma ...

Non-cancer control data were obtained from a publicly available database which included over 118,000 cases from the European population. A total of 39 different germline pathogenic variants were ...

Real-World Treatment Patterns After Discontinuation of Venetoclax or BTKis in the Frontline Setting Among Older Adults With Chronic Lymphocytic Leukemia Indications for and implications of germline ...

Novel research has shown that women are frequently denied MRI scans, despite usual recommendations. Read more.

The nucleus of a germline stem cell undergoes two divisions, firstly separating homologous chromosomes and secondly separating chromatids. Haploid gametes contain 23 single chromosomes.

A new paper in Genome Biology and Evolution finds that the link between paternal age and rare congenital disorders is more complex than scientists had previously thought.

The National Institute for Health and Care Excellence (NICE) has given a positive recommendation for Lynparza (olaparib) for ...

An expert spoke with CURE® about the importance of information that can be gained from genetic testing for patients with breast cancer. Germline testing, or genetic testing of the DNA that a person ...