Among various mutation types, loss of heterozygosity (LOH) events have garnered significant attention due to their high frequency, their impact on large portions of the genome, and their crucial role ...

This month's cover highlights the article A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets by Stacey D. Gilk, Rajendra Angara and Arif Sadi. The ...

If you have an inherited intolerance to alcohol, a mutated gene could be the culprit. An at-home DNA test could detect ...

Researchers have uncovered promising insights into Alzheimer’s disease through a study focusing on a Colombian family with a ...

The platform offers tumor purity estimation based on Allele Frequency based Imputation of Tumor Purity (All-FIT; DOI: 10.1093/bioinformatics/btz865), and mutational modeling of variants present in ...

A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.

引言癌症的发生和发展通常伴随着基因组的广泛改变，其中包括突变、拷贝数变异以及其他遗传改变。长久以来，人们普遍接受“二次打击假说”（Two-hit hypothesis），即肿瘤抑制基因（Tumor Suppressor Genes, ...

This important study reveals a critical role of the transcription factor NR2F2 in mouse fetal Leydig cell (FLC) differentiation. With elegantly carried out experiments, the authors provide compelling ...

You have full access to this article via your institution. As DelBank clones are useful only if they retain germline colonizing capability, 10 parental lines were evaluated by us and DelBank users ...

The assertion that the heart contains its own dedicated cardiomyocyte-producing stem cell is absolutely central to the entire cardiac regeneration–stem cell debate. If the heart truly lacks such an ...