研究小组还进行了几项分析，以评估类器官中基因和蛋白质的表达水平。他们的发现指出，在他们所研究的两种无脑畸形类器官中，mTOR（哺乳动物雷帕霉素靶点）通路都存在失调。 Louvi说：“这是控制细胞代谢的许多不同方面以维持细胞稳态的基本途径。

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to ...

In an eagerly awaited study, Memorial Sloan Kettering researchers report on the molecular structure of mTOR, a protein commonly mutated in cancer. Structural Biology Program Chair Nikola P. Pavletich ...

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions ...

Yale researchers identified an underactive mTOR pathway as a cause of lissencephaly and reversed brain malformations in ...

Researchers have identified a molecular mechanism driving the structural abnormalities leading to lissencephaly that have ...

The research team also performed several analyses to evaluate the gene and protein expression levels in the organoids. Their ...

Leucine is the most important of these for muscle protein synthesis and repair. It also plays a role in regulating the mTOR pathway. “The mammalian target of rapamycin (mTOR) signalling pathway ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...