Small GTPase RHEB is a well-known mTORC1 activator, whereas neddylation modifies cullins and non-cullin substrates to regulate their activity, subcellular localization and stability. Whether and how ...

Substrates or subfloors are the surfaces on which floorcovering materials are applied. They can be wood, concrete, plywood, stone or metal. Regardless of the material, there are specific ...

The importance of these substrates for immune function would suggest that an intracellular sensor, such as mTORC1, is required to monitor their presence and metabolism in the cell 65. Indeed ...

Aging involves gradual functional decline across various biological systems, including impaired cellular mechanisms such as ...

In this study, we analysed its mechanistic association and functional relationship in OA progression in chondrocyte lineage. Conclusions Our findings indicate that Wnt16 activates PCP/JNK and ...

2024年12月16日，复旦大学脑科学研究院/脑功能与脑疾病重点实验室高艳琴教授团队联合许智祥研究员团队，在Advanced Science上 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Thermogenic fat, including brown and beige fat ...

#AB152, RRID:AB_390204) staining and visualized using the Vectastian Elite ABC Kit (Vector Labs, Cat. PK-6101) and the DAB peroxidase substrate kit (Vector Labs, Cat. SK-4100) following the ...

Lung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to ...

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China ...

Then sections were incubated with primary antibody (anti-Ki67) at 4 °C overnight. The slides were then washed with PBS (PH=7.4) and incubated with secondary antibody for 1 h at 25°C, and then stained ...