Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial ...

Losing weight is a goal that many people often feel is impossible to achieve. Dieting demands strict guidelines, and workouts ...

Our results indicated that MKO cell respiration was affected by all three inhibitors ... There was also an imbalance in metabolites associated with the urea cycle, such as citrulline and ornithine.

This developmental plasticity requires a strict temporal and spatial control of the cell cycle. Cell-cycle activation in quiescent cells is correlated with a change in chromatin structure and ...

近年来，有关二甲双胍作用机制的研究层出不穷；其中腺苷酸活化蛋白激酶（AMPK）信号通路在 ... 2022,603(7899):159-165. [7]He L, et al. Cell. 2009 May 15;137(4 ...

A large-scale single-cell study shows aging happens in specific stages driven by molecular cues, offering targets to modify the aging process and revealing key age and sex-related cellular differences ...

编后记： 回顾过去的AMPK溶酶体激活通路到今天的这两篇工作，林老师对编者感叹，他的课题组从发现（低）葡萄糖感知通路是延长寿命的核心轴（林圣彩组Nature破解葡萄糖感受的新机制；Cell Metabolism丨林圣彩团队贯通葡萄糖感知通路）【8-10，15】，到发现该 ...

AMPK（AMP-活化蛋白激酶）作为能量代谢的关键调控者，一直被认为是CR带来抗衰老效益的重要介质。在热量限制条件下，AMPK的激活能够调节细胞能量 ...